- Description
- Additional Information
- Readable Documents
- Assay Principle
- Reviews
Introduction
Sarcosine is natural amino acid that is an important intermediate in the metabolism of choline. Sarcosine is an important component of proteins and plays a significant role in metabolic processes of living cells as a source of serine, creatine, purines and glutathione etc. Sarcosine is present in food sources like legumes, eggs, ham, turkey etc. It is used in a variety of industrial applications such as manufacturing of tooth paste and biodegradable surfactants. Sarcosine was recently reported to activate prostate cancer cells and as a possible marker for prostate cancer progression to metastasis(1). It is also used in adjunctive treatment for Schizophrenia (2) and depression (3).
Cell Technology’s Fluoro Sarcosine assay provides a reliable, sensitive fluorimetric method for the quantification of sarcosine in biological samples.The Fluoro Sarcosine detection kit utilizes a non-fluorescent detection reagent, which is reduced via an enzyme-coupled reaction in the presence of sarcosine. A sarcosine standard curve is generated to quantify sarcosine in the samples.
Key Benefits
- Easy to Use – No Wash Assay.
- Detection of Sarcosine in cells, serum, tissue extracts.
- Easy to Use 96-well Fluorescent Plate reader readout.
Additional information
| Kit Size | 100 |
|---|
| Document Title |
| Fluoro Sarcosine Protocol |
| Fluoro Sarcosine Datasheet |
| msds.fluoroSarcosine |
| Reference |
| Sreekumar, Arun; Poisson, Laila M.; Rajendiran, Thekkelnaycke M.; Khan, Amjad P.; Cao, Qi; Yu, Jindan; Laxman, Bharathi; Mehra, Rohit et al. (2009). "Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression". Nature 457 (7231): 910. doi:10.1038/nature07762. PMID 19212411. |
| Lane H, Huang C, Wu P, Liu Y, Chang Y, Lin P, Chen P, Tsai G (2006). "Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia". Biol Psychiatry 60 (6): 645–9. doi:10.1016/j.biopsych.2006.04.005. PMID 16780811. |
| images/CellTechnology/NCT00977353 Clinicaltrials.gov "N-methylglycine (Sarcosine) Treatment for Depression". |
| Part# | Reagent | Temperature |
| Part # 6024 | Enzyme Mix, 1 Vial | -20C |
| Part # 3056 | Standard Curve Diluent, 40mL | 2-8C |
| Part # 4023 | Sarcosine Detection Reagent, 1 Vial | 2-8C |
| Part # 7021 | Sarcosine Standard, 1 Vial | 2-8C |
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